![]() Disease-modifying drugs for hand OA are currently not available. The healthcare costs for treating this condition are expected to escalate due to the ageing population and increasing obesity. Hand OA impairs the activities of daily living such as dressing and eating, with significant clinical importance in relation to health-related quality of life. In people aged 55 years and over, 67% of the women and 54.8% of the men have radiographic OA in at least one hand joint, with 20% having disabling pain. The lifetime risk of symptomatic hand OA is 39.8% in the general population, 47.2% for females and 24.6% for males. Hand osteoarthritis (OA) is a common chronic joint disease causing pain, functional disability, and decreased quality of life which result in substantial burden of disease. Trial registrationĪustralian New Zealand Clinical Trials Registry (ANZCTR), ACTRN12620000599976. This study will provide high-quality evidence to determine whether topical corticosteroid reduces pain over 6 weeks in patients with hand osteoarthritis, with major clinical and public health importance by informing clinical practice guidelines for the management of hand osteoarthritis and reducing the burden of the disabling disease. The primary analysis will be by intention to treat, including all participants in their randomised groups. The secondary outcomes include changes in pain and function assessed using Functional Index for Hand Osteoarthritis, Australian Canadian Osteoarthritis Hand Index, Michigan Hand Outcomes Questionnaire, and tender and swollen joint count at 6 weeks. The primary outcome is pain reduction (assessed by 100 mm visual analogue scale) at 6 weeks. One hundred participants with hand osteoarthritis will be recruited from the community in Melbourne, Australia, and randomly allocated in a 1:1 ratio to receive either topical Diprosone OV or placebo ointment administered 3 times daily on the painful hand joints for 6 weeks. The aim of this randomised, double-blind, placebo-controlled trial is to determine whether topical corticosteroid reduces pain over 6 weeks in patients with hand osteoarthritis. ![]() Corticosteroids are potent anti-inflammatory drugs used in many rheumatic diseases. Emerging evidence suggests the role of local inflammation in causing pain in hand osteoarthritis. ![]() Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies. ![]()
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